can you take astragalus at night

View abstract. View abstract. View abstract. Journal of Emergency in Traditional Chinese Medicine 2005;14(11):1070-1071. Astragalus has active ingredients of astragalus. View abstract. They experienced greater improvements in heart function compared to those receiving standard treatment alone (15). Chinese Journal of Tissue Engineering Research and Clinical Rehabilitation 2007;11(23):4531-4533. View abstract. Modern Journal of Integrated Traditional Chinese and Western Medicine 2005;14(5):610. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Chem.Pharm Bull. Shi, H. M., Dai, R. H., and Wang, S. Y. The most important thing is to. Hypoglycemic effect of astragalus polysaccharide and its effect on PTP1B. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Its important to keep in mind that when we talk about astragalus we are talking about the speciesAstragalus membranaceus. Wang, J. J., Li, J., Shi, L., Lv, X. W., Cheng, W. M., and Chen, Y. Y. Its thought to widen your blood vessels and increase the amount of blood pumped from your heart (14). Effects of astragalus on IL-2/IL-2R system in patients with maintained hemodialysis. Chin J Integr.Med 2006;12(4):262-267. Chen, Z. Lei, Z. Y., Qin, H., and Liao, J. This green powder is made with organic veggies that also helps to provide the energy that you need to get through the day and it is filled with adaptogens as well. 2003;23(10):733-735. J Clin Oncol 2006;24:419-30. I call it wired but tired. It's when youre burnt out but a little anxious, she says. The effect of Astragalus on diabetic nephropathy. A clinical investigation on 30 cases of senile benign renal arteriosclerosis treated bu Huang qi gu jing yin. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Peng, M. H., Wang, X. Y., Sun, F. Y., Du, X. Kim, C., Ha, H., Lee, J. H., Kim, J. S., Song, K., and Park, S. W. Herbal extract prevents bone loss in ovariectomized rats. [Effect of Astragalus membranaceus on Ca2+ influx and coxsackie virus B3 RNA replication in cultured neonatal rat heart cells]. Lishizhen Medicine and Materia Medica Research 2007;18:1743-1744. View abstract. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Do not give astragalus supplements to a child with a fever as this can make their condition worse. View abstract. However, astragalus only appeared to be helpful during the first week of treatment (21). Fang Z, Qin Y. Can you take astragalus at night? View abstract. ", Integrative Cancer Therapies: "Immune system effects of echinacea, ginseng, and astragalus: a review. Astragalus may support kidney health by improving blood flow and laboratory markers of kidney function, such as measures of protein in the urine. Liu Y, Li Y. J Nat Toxins 1999;8:35-45. View abstract. Modern Journal of Integrated Traditional Chinese and Western Medicine 2005;14:988-989. Wang, F., Xiao, M. D., and Liao, B. Make sure you purchase astragalus supplements from a reputable herbal supplier. It has also been shown that astragalus supplements can help to protect your kidneys and be used to treat kidney disease. Doses of up to 60 grams per day have been safely used for up to 4 months. Yuan, Y., Sun, M., and Li, K. S. Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8. Astragalus is considered an adaptogen. Clinical observation of Huangqi Injection for congestive heart failure. Do not take Astragalus membranaceus if you are allergic to astragalus or any ingredients contained in this drug. Astragalus is an amazing dietary supplement that you should consider taking for it not only being able to help boost your immune system, but also for many other health benefits as well. Yong WU, Yand OU, Ping J, Ke WU, and et al. Herald of Medicine 2003;22(8):556-557. Here are the 20 best foods to eat if you have kidney disease. Theres still limited research on astragalus, but it has uses in treating the common cold, seasonal allergies, heart conditions, kidney disease, chronic fatigue and more (5, 6). Xiao, H. B., Krucker, M., Albert, K., and Liang, X. M. Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. 2011;11(2):142-148. Chen, P. Y., Zhou, F., Chen, W. L., Ceng, Y., and Luo, L. Y. Speak to your doctor before you use astragalus supplements to treat your diabetes. By promoting overall health, metabolic efficiency, and hormonal balance, astragalus can help to deliver , restful sleep. Most widely known as astragalus (aka. Astragalus root is an adaptogen herb that aids the body in dealing with a variety of stressors, including chemical, physical and emotional stress. The University of Texas has shown it to be an adaptogenic herb which enables viruses, bacteria, and even cancer cells to be "picked up" on the immune system's radar. Acta Pharmacol.Sin. Cochrane.Database.Syst.Rev. Yang, H. Y., Li, J., and Yi, M. [Study on chronical hepatitis B with treatment of integrative traditional Chinese and Western medicine]. The primary role of your immune system is to protect your body against harmful invaders, including bacteria, germs and viruses that can cause illness (7). ", Phytotherapy Research: "Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis.". 2005;26(3):345-352. Am J Otolaryngol. View abstract. View abstract. [Effect of Astragalan on secretion of tumor necrosis factors in human peripheral blood mononuclear cells]. Dr. Wattles points out that astragalus is a source of antioxidants, so its plausible that it offers benefits similar to those of other antioxidants. Central Plains Medical Journal 2003;30(14):6-7. View abstract. 1992;12(10):579, 588-592. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Chemotherapy-induced nausea and vomiting (CINV), Vitamins and Supplements to Avoid with Hepatitis C, Diabetes. 2008;28(6):544-547. J.Tradit.Chin Med. View abstract. McCulloch M, See C, Shu XJ, et al. Clinical Focus 1997;12(14):657-658. You can choose supplements that meet independent quality standards from ConsumerLab.com, NSF, or USP. Zhou, Z. H. Effect of Huangqi injection in reducing microalbuminuria for patients with type 2 Diabetes. Xie, B. X. Number of Warfarin sodium and Astragalus reports submitted per year: Common Warfarin Sodium and Astragalus drug interactions by gender *: female: Chronic kidney disease Renal injury Traditional Chinese medicine holds that children with a fever should not take astragalus because it may increase the fever and result in it lasting longer. Symptoms, Causes, Diagnosis, Treatment, and Prevention, Zhang J, et al. Different foods can affect the function of your kidneys. Make sure you water deeply to help germination. Song, J. Y., Meng, L. Q., and Li, X. M. [Therapeutic application and prospect of Astragalus membranaceus and Angelica sinensis in treating renal microvascular lesions]. J Pharm.Pharmacol. A tea containing 6 to 12 g of dried root in 12 ounces of water can be used three times daily, and 500 to 1,000 mg of powdered root is taken three to four times a day. Astragalus is an herb thats been used in traditional Chinese medicine for many centuries to boost the immune system. In case of overdose, get medical help or contact a Poison Control Center immediately. [Clinical evaluation of the antioxidant activity of astragalus in women with gestational diabetes]. Astragalus supplements may be a good option for you if you are looking for a natural, herbal way to treat certain medical issues, with the help of your physician. Do not give astragalus supplements to a child with a fever as this can make their condition worse. 1992;12(11):669-71, 645. If you are interested in taking dietary astragalus supplements, then you should take 200mg twice a day . Huanqi the treatment of viral myocarditis caused by the clinical research of arrhythmia. Never go off of your diabetes medication until you speak to your doctor. 2009;29(4):313-316. Wang, Y. G. An X. J. Wu X. Sun Y, Hersh EM, Lee SL, et al. Astragalus root can be found in many different forms. Chinese Journal of Information on Traditional Chinese Medicine 1998;5(12):51. Int.J Mol.Med 2009;23(2):189-196. poisoning in livestock. Clinical observation of Huangqi injection for congestive heart failure. Wu, B. Q. Astragalus root can be found as a capsule, liquid extract, or tea. 2005;25(10):872-875. Journal of Practical Emergency Medicine Integrated Chinese and Western Medicine 1999;6:230-231. Li, Q., Li, F., and Lu, J. Extractum Nucis Vomicae for the Peripheral Nerve Pressure Symptoms of Cervical Spondylopathy: a Randomized Control Observation of 306 Cases. There are lots of supplements to take to boost your immune system, and one of the best ones that you can take is astragalus. I drink a lot of coffee. Zhang J, Jia L Du Y. Qian, Z. W., Mao, S. J., Cai, X. C., Zhang, X. L., Gao, F. X., Lu, M. F., Shao, X. S., Li, Y. Y., Yang, X. K., Zhuo, Y. If you have a sore throat, astragalus tea can coat those irritated membranes, she says. J Clin Lab Immunol 1988;25:119-23. Am.J.Chin Med. 2004;29(2):152-153. Chu G, Peng X. Astragalus injection as assisted treatment for refractory heart failure. 2009;29(5):381-385. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Xu, G. H., Yuan, L., Li, Y., Xie, P., Zhao, J. Y., and Chen, Y. H. [Clinical observation of Astragalus Injection in treatment of renal injury in patients with primary hypertension]. Wu, H. M., Tang, J. L., Cao, L., Sha, Z. H., and Li, Y. 2003;26(11):917-924. View abstract. View abstract. 2008;11(3):244-251. Yang Y, Jin P, Guo Q, and et al. Cho, W. C. and Leung, K. N. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. Chen, M. L., Liu, W. J., Wang, C. Y., Zhu, X. M., Yin, J. F., Wang, D. X., and Liu, P. [Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats]. Acetyl-l . Zhang HW, Lin ZX, Xu C, Leung C, Chan LS. Clinical therapeutic effect observation of different doses of Huangqi injection for congestive heart failure. Shen, P., Liu, M. H., Ng, T. Y., Chan, Y. H., and Yong, E. L. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. Is Astragalus an antiviral? Zhong Xi Yi Jie He Za Zhi 1989;9(11):656-7, 644. Su, Y. C., Lin, C. J., Chen, K. T., Lee, S. M., Lin, J. S., Tsai, C. C., Chou, Y., and Lin, J. G. Effects of huangqi jianzhong tang on hematological and biochemical parameters in judo athletes. [Effect of Astragalus on cytokines in patients undergoing heart valve replacement]. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. And thats a lot Wattles considers 30 g a high dose. Dai, F. and Long, Y. C. Combined Chinese and Western treatment of chronic hepatitis B: an analysis of 38 cases [in Chinese]. Harbin Med 1997;17(3):50-52. You can get a tincture of astragalus in 30 percent ethanol. View abstract. Glycine is a neurotransmitter with the ability to be both excitatory and inhibitory, meaning it can function both to stimulate brain and nervous systemactivity, or to quiet it. Current item Solaray, Astragalus, 550 mg, 100 VegCaps See price in cart. Hebei Journal TCM 2002;24(4):308-309. Liu, J. P., McIntosh, H., and Lin, H. Chinese medicinal herbs for asymptomatic carriers of hepatitis B virus infection. Hoo, R. L., Wong, J. Y., Qiao, C., Xu, A., Xu, H., and Lam, K. S. The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. She is a member of the Arkansas Academy of Nutrition and Dietetics. Astragalus is believed to prolong life and used to treat a wide variety of ailments, such as fatigue, allergies and the common cold. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. The root may also be ground into a powder, which can be brewed into teas (2). Acta Pharmacol.Sin. Journal of Traditional Chinese Medicine 1986;27(4):37-39. Specifically, the root of the plant is made into many different forms of supplements, including liquid extracts, capsules, powders and teas. Astragalus benefits the immune system via its immunoregulatory properties. Here are some common negative reactions to ashwagandha: 1. 2002;22(7):515-517. View abstract. Some astragalus species, usually not found in dietary supplements, can be toxic to livestock. 2010;7:CD003711. Liu, Z. L., Liu, Z. J., Liu, J. P., and Kwong, J. S. Herbal medicines for viral myocarditis. In animal and test-tube studies, astragalus has been shown to improve sugar metabolism and reduce blood sugar levels. Zhonghua Nan.Ke.Xue. Clin Invest Med 2012;35(1):E1-11. Studies indicate that astragalus supplements may help control blood sugar levels in people with type 2 diabetes. 2012;11:CD003711. Taixiang, W., Munro, A. J., and Guanjian, L. Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. "Digestion slows down during sleep, so taking your nutrient supplement late at night would not be associated with an efficient absorption." Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. In Chinese, it's called huang qi, which means "yellow life energy." That's because the root is . Keep out of reach of children. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(5):268-70, 259. Insomnia Tied to Dramatic Rise in Heart Attack Risk, Just 500 Extra Steps a Day Can Lower Heart Disease Risk in Seniors, Study Suggests. 4 You shouldn't use astragalus without a healthcare practitioner's recommendation if you have autoimmune diseases such as: Crohn's disease Multiple sclerosis Psoriasis Rheumatoid arthritis Type 1 diabetes Systemic lupus erythematosus (SLE) [Effects of large dose of Astragalus membranaceus on the dendritic cell induction of peripheral mononuclear cell and antigen presenting ability of dendritic cells in children with acute leukemia]. Zhao, K. W. and Kong, H. Y. Ma L, Yu J Han Y. Shiyuanfu means to be taken away from mealtime; linshiuqianfu means to be taken before bedtime; and kongfufu means to be taken with an empty stomach (e.g., before breakfast). Claudia received her MS in Nutrition from the University of Tennessee Knoxville in 2010. Fu, S., Zhang, J., Menniti-Ippolito, F., Gao, X., Galeotti, F., Massari, M., Hu, L., Zhang, B., Ferrelli, R., Fauci, A., Firenzuoli, F., Shang, H., Guerra, R., and Raschetti, R. Huangqi injection (a traditional Chinese patent medicine) for chronic heart failure: a systematic review. Having high blood sugar levels is a common issue for people with diabetes and prediabetes. People who are pregnant or chestfeeding should not take astragalus, as experts suggest it may be toxic to the parent or child. View abstract. Luo X. 2001;21(4):254-256. Speak to your doctor before taking astragalus supplements if you are taking other herbal medications or treatments. Li, L. Diabetic nephropathy treating with Astragalus. Life Sci 8-15-2006;79(12):1186-1193. [Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines]. These are made by boiling the astragalus root to release its active compounds. 8-1-1996;12(4):386-393. pii: E1318. Wu, J., Wang, Y. X., Su, W. L., Zhu, W. X., Lu, J. W., and Li, Z. K. Effect of astragalus injection on serious abdominal traumatic patients' cellular immunity. View abstract. Santa Cruz, CA: American Herbal Pharmacopoeia. Z., Xiang, D. P., and Wang, W. S. [Observation of therapeutic effect of Astragalus membranaceus by acupoint injection for treatment of hepatitis B virus carriers]. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2. View abstract. View abstract. You can learn more about adrenal dysfunction, as well as how to address and treat it through an at-home protocol, . Shanxi Medical Journal 2005;34(7):860-861. View abstract. This is also a supplement that you can take with or without food. 1999:1-25. Journal of Shanxi College of Traditional Chinese Medicine 2006;29(3):19-20. Chao, M., Zou, D., Zhang, Y., Chen, Y., Wang, M., Wu, H., Ning, G., and Wang, W. Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. View abstract. The Food and Drug Administration (FDA) does not regulate supplements for content, potency, labeling, or claims. View abstract. Anti-Tumor Effects and Mechanisms of, Zhang Y, et al. 2005 - 2023 WebMD LLC. Yang, R. F. Application of Astragalus injection on 56 patients with diabetic nephropathy. In animal research, astragalus root has been shown to help kill bacteria and viruses in mice with infections (9, 10). Can you take astragalus at night? Oncol.Rep. View abstract. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. For burns, use a 10 percent astraglus topical ointment, as directed by your physician. Astragalus roots are powdered and used as a dietary supplement. J Tradit.Chin Med 2005;25(1):21-22. View abstract. If your medical condition is not improving, you may talk to your doctor about trying a different herbal medicine or switching to other medication. Cochrane Database Syst.Rev. View abstract. [Effects of Ailing Granule on immuno-reconstruction in HIV/AIDS patients]. It may also be injected in a medical setting., While there is still limited research on the health benefits of astragalus, it contains many active plant compounds that may be responsible for its healing properties, like strengthening the immune system and reducing inflammation., The compounds in astragalus may enhance and support your immune system. Journal of Liaoning College of TCM 2004;6(5):390. 1995;15(8):462-464. Astragalus may have negative interactions with other medications or supplements. View abstract. Astragalus (Astragalus . 2008;6(5):530-532. 3 Several preliminary clinical trials in China have suggested that astragalus can benefit immune function and improve survival in some people with cancer. Practical Journal of Medicine and Pharmacology 2006;23:439-440. A few people who take astragalus orally have reported rashes, itching, nasal symptoms, or stomach discomfort. 2005;1-72. 2005;33(1):127-138. Immune restoration and/or augmentation of local graft versus host reaction by traditional Chinese medicinal herbs. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. ~ $11 / 90 capsules. Geng, C. S. [Advances in immuno-pharmacological studies on Astragalus membranaceus]. Cochrane.Database.Syst.Rev. Zeng, C. F. Clinical observation on 25 cases of acute viral myocarditis treated with combined method of Chinese and western medicine. For adults, the University of Maryland Medical Center suggests taking 250 to 500 mg standardized extract three to four times daily. Similarly, several other studies have demonstrated benefits of the herb for nausea and vomiting in individuals undergoing chemotherapy for colon cancer (20). Clinical observation on the effect of Radix Astragali in the treatment of viral myocarditis complicated with ventricular premature beat and in the regulation of immunologic function. Clinical observation of Huangqi injection for the treatment of pulmonary heart disease refractory heart failure. Chinese Journal of Clinical Rehabilitation 2005;9(46):102-104. Image courtesy of Mountain Rose Herbs.. Treatment of adult diabetes with Jiangtangjia tablet. Wu, J. H., Li, Q., Wu, M. Y., Guo, D. J., Chen, H. L., Chen, S. L., Seto, S. W., Au, A. L., Poon, C. C., Leung, G. P., Lee, S. M., Kwan, Y. W., and Chan, S. W. Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways. So if you are interested in taking astragalus, you must now be wondering what time of day you should take it so you can get the best results possible. Effects of the traditional Chinese herb Astragalus membranaceus in patients with poststroke fatigue: A double-blind, randomized, controlled preliminary study. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2003;10(1):60-1. There should be legitimate contact information for the supplier on the label and the ingredients should state that the supplement contains mostly or only astragalus. Ma Z, Cheng X Wang L. Huangqi injection as the assisted treatment for 86 cases with chronic pulmonary heart failure. View abstract. Am J Kidney Dis. Traditional Chinese Medicine for treatment of cerebral palsy in children: a systematic review of randomized clinical trials. Some recommend boiling the astragalus directly into a tea to release its active compounds., While there's no official recommendation for the most effective astragalus dosage, 9 to 30 grams per day is a typical dose. Journal of Shanxi Medical College of Continuing Education 1999;9(1):39-40. [Extracorporeal experimental study on immuno-modulatory activity of Astragalus memhranaceus extract]. J Nat.Med 2009;63(4):421-429. A combination of Chinese herbs, Astragalus membranaceus var. View abstract. What Time of Day Should You Take Astragalus. You can also brew it as a tea. Journal of Chinese Practical Medicine 2000;2(9):72. 2006;31(15):1277-1280. Researchers from Texas have suggested that taking astragalus extract can prolong the life of cancer patients while studies on animals have shown that astragalus has potential anti-tumor effects against certain types of cancer including leukemia and melanoma.. View abstract. Hubei Journal of Traditional Chinese Medicine 2002;24(9):11-12. 2007;5(3):272-275. Similarly, astragalus supplements have been shown to help treat seasonal allergies like hay fever or allergic rhinitis. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Scand J Clin Lab Invest 1997;57:521-7. For example, 7.515 grams of astragalus taken daily for three to six months reduced the risk of infection by 38% in people with a kidney disorder called nephrotic syndrome. Nutr Metab (Lond) 2010;7:67. He H, Zhou X, Wang Q, Zhao Y. View abstract. Shanghai Medical & Pharmaceutical Journal 1995;11:11-12. Drugs.com recommends drinking extra fluids with this herbal medicine, as it can cause a blockage in your esophagus or bowels. Though no dosage recommendation exists, up to 60 grams daily for up to four months appears to be safe for most people. View abstract. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(3):142-144, 131-2. Zhejiang JLTCWM 2005;15(1):32. 2009;50(5-6):185-193. 2009;30(12):1607-1615. Fan L. Observation of Chinese and Western medicine for the treatment of 72 cases with congestive heart failure. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. J Clin Pharm Ther. Its also used against heart disease, diabetes and other conditions. Journal of Zhenjiang Medical College 2001;11:168-169. China Tropical Medicine 2007;7(8):1343-1344. Yang, Y. X. Journal of Shaanxi College of Traditional Chinese Medicine 2000;23(4):46-47. Our website services, content, and products are for informational purposes only. It may be, if you're taking up to 60 grams (g) a day by mouth for up to four months. Dig and twist until a good portion of the root comes out. The pathogenesis and toxicokinetics of locoweed (Astragalus and Oxytropis spp.) 5 How does astragalus root extract help with sleep issues? Effects of Astragalus membranaceus on plasma BNP and NT-BNP during chronic heart failure. Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride-induced hepatic fibrosis. (Tokyo) 1991;39(11):2969-2972. It is also advised to avoid using astragalus while pregnant or breastfeeding because of harmful effects that have been shown in preliminary studies. Chin J Integr Med 2011;17(2):146-149. Gao Z, Zhang L Xu Y Liu L Zhang L. Clinical observation of Astragalus injection for congestive heart failure. Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Phyllis A. Balch, author of "Prescription for Herbal Healing," states that it works to suppress some immune functions while enhancing others. newry, mourne and down council jobs, what is repatriation hospital,

Coast Guard Cape May Graduation 2022, Rana Wehbe Watson, Busch Gardens St Louis Amusement Park, Articles C

Ir al Whatsapp
En que lo podemos ayudar ?